Unpublished paper, 'Experimental observations on the early degenerative changes in the sensory end organs of muscles' by Frederick E [Eustace] Batten

Description

Batten conveys a series of experiments undertaken in order to show, firstly, that degeneration occurrs in the first place in that part of the neuron most remote from the cell, and secondly, to reproduce within the muscle-spindle, if possible, certain changes which have been shown by the author to be present in the case of tabes dorsalis [locomotor ataxia] in man. In Batten's experiments, dogs are selected, and the mixed roots of the fifth cervical to the first dorsal inclusive are divided, and the animals killed 24, 48, 72, 96, 120 hours, and 7 and 14 days after section of the nerve. Bicep muscles are treated by Sihler's method and muscle-spindles are teased out; some of these are mounted without further staining while others are treated by Marchi's method or the Marchi-Pal method.

Annotations in ink throughout. Includes three pages of photographs of muscles.

Subject: Physiology

Received 17 February 1898. Read 3 March 1898. Communicated by Victor Horsley.

Whilst the Royal Society declined to publish this paper in full, an abstract of the paper was published in volume 63 of the Proceedings of the Royal Society as 'Experimental observation on the early degenerative changes in the sensory end organs of muscles'.

Reference number

AP/73/14

Earliest possible date

1898

Physical description

Ink on paper

Page extent

25 pages

Format

Typescript
Photograph